WRECKED REGULATION OF INTRINSICALLY DISORDERED PROTEINS IN DISEASES: PATHOGENICITY OF DEREGULATED REGULATORS

Biologically active proteins without stable tertiary structure are common in all known proteomes.Functions of these intrinsically disordered proteins (IDPs) are typically related to regulation, signaling and control.Cellular levels of these important regulators are tightly regulated by a variety mechanisms ranging from firmly controlled expression

Background: Traditionally believed to be an integral part of multiple myeloma (MM) treatment, the role of hematopoietic stem-cell transplantation (HSCT) is being challenged.As such, we sought to evaluate the impact of HSCT in the era of novel agents.Methods: A multicenter, retrospective, longitudinal cohort study was carried out between January 201